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Baseline screening complete blood count with platelet count recent chest xray liver function tests aspartate aminotransferase ast alanine aminotransferase alt alkaline phosphatase albumin consider hepatitis b and hepatitis c serologies renal function tests creatinine follow-up monitoring monthly x3, then every 8 weeks complete blood count with platelet count liver function tests aspartate aminotransferase ast alkaline phosphatase renal function tests creatinine liver biopsy indications cumulative methotrexate dose 8 gram prior heavy alcohol use persistently elevated ast sgot 2-3x normal psoriatic arthritis.